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题名: A cyanine-based near-infrared fluorescent probe for highly sensitive and selective detection of hypochlorous acid and bioimaging
作者: Li, Huihui1, 2; Guan, Lingmei3; Zhang, Xiaojie3; Yu, Huan1; Huang, Dejian4; Sun, Mingtai1; Wang, Suhua1, 2
关键词: Fluorescent ; Near-infrared ; Hypochlorous acid ; Cell imaging
刊名: TALANTA
发表日期: 2016-12-01
卷: 161, 页:592-598
收录类别: SCI
英文摘要: Hypochlorous acid (HOCl) is a kind of reactive oxygen species which plays an important role in biological process. HOCl detection is of great importance in disease prevention and treatment. Herein, a cyanine-based near-infrared (NIR) fluorescent probe for HOC! has been designed and synthesized. This probe can react with HOC! in a dose-response manner along with the fluorescence of the probe quenched, the reaction through an electrophilic addition to the double bond and subsequent oxidation reaction. Experiments indicate that the probe can be acted as a selective and sensitive indicator for HOCl and the limit of detection for HOC! is estimated to be 22 nM. What's more, this probe shows a low toxicity to cells and can be applied to visualize HOCl molecules in living cells. Therefore, the proposed method may make a significant contribution to HOCl detection. (C) 2016 Elsevier B.V. All rights reserved.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35088
Appears in Collections:分子动态与稳态结构实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Intelligent Machines, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China
4.Natl Univ Singapore, Dept Chem, Food Sci & Technol Programme, 3 Sci Dr 3, Singapore 117543, Singapore
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